Sulfasalazine inhibition of binding of N-formyl-methionyl-leucyl-phenylalanine (FMLP) to its receptor on human neutrophils.

doi:10.1016/0006-2952(84)90233-8

Paper

DOI: 10.1016/0006-2952(84)90233-8

Sulfasalazine inhibition of binding of N-formyl-methionyl-leucyl-phenylalanine (FMLP) to its receptor on human neutrophils.

Published Feb 1, 1984 · William F. Stenson, William F. Stenson, William F. Stenson

Biochemical pharmacology

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Abstract

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Study Snapshot

Sulfasalazine effectively blocks FMLP-induced arthritis in rabbits and superoxide production and chemotaxis in human neutrophils, with a 10 M dose-response curve.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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The oligopeptide chemotactic factor receptor on human polymorphonuclear leukocyte membranes exists in two affinity states.

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5,8,11,14-Eicosatetraynoic acid (ETYA) inhibits binding of N-formyl-methionyl-leucyl-phenylalanine (FLMP) to its receptor on human granulocytes. A note of caution.

ETYA inhibits cAMP and superoxide responses in human granulocytes by inhibiting FMLP binding to its receptor, rather than inhibiting arachidonate metabolism.

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Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils.

Sulfasalazine, a common treatment for ulcerative colitis, blocks the synthesis of chemotactic lipids by neutrophils, potentially reducing inflammation and promoting healing.

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Citations

DOI: 10.1016/j.freeradbiomed.2022.08.039

Propofol metabolites and derivatives inhibit the oxidant activities of neutrophils and myeloperoxidase.

Propofol metabolites and derivatives PPFQ and PPFDQ can contribute to its anti-inflammatory action by inhibiting neutrophil oxidative responses and myeloperoxidase activity.

2022·3citations·P. Nyssen et al.·Free radical biology & medicine

Free radical biology & medicine

DOI: 10.1136/bmjopen-2021-057214

Helicobacter pylori infection in patients with inflammatory bowel diseases: a single-centre, prospective, observational study in Egypt

The association between IBD and H. pylori infection is unresolved, but eating fruits and vegetables may protect against IBD flares.

2022·3citations·E. A. Abd El-Wahab et al.·BMJ Open

BMJ Open

DOI: 10.1080/09273948.2021.1873396

Mesalazine Suppresses Proinflammatory Cytokines in Patients with Acute Anterior Uveitis Independently of HLA-B27

Mesalazine suppresses proinflammatory cytokines and markers in patients with acute anterior uveitis regardless of HLA-B27 status, but the mechanism of HLA-B27 status determining therapeutic response remains unclear.

2021·1citation·N. Smatlik et al.·Ocular Immunology and Inflammation

Ocular Immunology and Inflammation

DOI: 10.5772/intechopen.90009

Traditional Drugs: Mechanisms of Immunosuppressor and Corticosteroid Therapies for Inflammatory Bowel Diseases

Immunosuppressor and corticosteroid therapies effectively control inflammation in inflammatory bowel diseases like Crohn's disease and ulcerative colitis by suppressing mucosal immunity and reducing inflammation.

2019·1citation·C. R. B. Cardoso et al.·Biological Therapy for Inflammatory Bowel Disease

Biological Therapy for Inflammatory Bowel Disease

DOI: 10.12998/wjcc.v6.i13.641

Helicobacter pylori may be an initiating factor in newly diagnosed ulcerative colitis patients: A pilot study

Helicobacter pylori can be detected in colonic tissue of newly diagnosed ulcerative colitis patients, suggesting an association between the two conditions.

2018·17citations·Loai Mansour et al.·World Journal of Clinical Cases

World Journal of Clinical Cases