A method using calcium triflimide [Ca(NTf2)2] as a Lewis acid to activate sulfonyl fluorides toward nucleophilic addition with amines is described. The reaction converts a wide array of sterically and electronically diverse sulfonyl fluorides and amines into the corresponding sulfonamides in good yield.

Calcium triflimide effectively activates sulfonyl fluorides for nucleophilic addition with amines, resulting in diverse sulfonamides with high yields.

Paper

Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides.

References

Citations