Suppression of L-histidine decarboxylase mRNA expression by methyleugenol.

doi:10.1006/BBRC.1997.6260

Paper

Suppression of L-histidine decarboxylase mRNA expression by methyleugenol.

Published Mar 6, 1997 · B. Shin, E. Lee, H. Kim

Biochemical and biophysical research communications

64

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Abstract

We investigated the effect of methyleugenol on anaphylaxis. Methyleugenol completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. Methyleugenol also inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Moreover, methyleugenol dose-dependently inhibited histamine release in mast cells activated by compound 48/80 or anti-DNP IgE. Northern-blot analysis demonstrated that significantly reduced level of the mRNA of L-histidine decarboxylase (HDC) was expressed in mast cells treated with methyleugenol, compared to that without methyleugenol. We conclude that methyleugenol directly affect histamine release and HDC gene over-expression in mast cells.

Non-RCTAnimal Study

Study Snapshot

Methyleugenol inhibits anaphylaxis by directly affecting histamine release and HDC gene over-expression in mast cells, reducing anaphylaxis-related symptoms.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Suppression of L-histidine decarboxylase mRNA expression by methyleugenol.

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