The synergism of n-hexane-induced neurotoxicity by methyl isobutyl ketone following subchronic (90 days) inhalation in hens: induction of hepatic microsomal cytochrome P-450.

doi:10.1016/0041-008X(85)90114-0

Paper

DOI: 10.1016/0041-008X(85)90114-0

The synergism of n-hexane-induced neurotoxicity by methyl isobutyl ketone following subchronic (90 days) inhalation in hens: induction of hepatic microsomal cytochrome P-450.

Published Oct 1, 1985 · Mohamed B. Abou-Donia, D. Lapadula, Gerald Campbell

Toxicology and applied pharmacology

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Abstract

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Non-RCT

Animal Study

Study Snapshot

Methyl isobutyl ketone (MiBK) synergizes the neurotoxic action of n-hexane in hens, potentially due to its ability to induce liver microsomal cytochrome P-450, leading to more potent neurotoxic metabolites.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

DOI: 10.1002/0471435139.TOX076.PUB2

Ketones of Six to Thirteen Carbons

Ketones of carbon number 6-13 are important commercial and industrial materials, contributing to smog formation and inhalation and dermal exposure, with rare cases of narcosis.

2012·3citations·J. O’Donoghue·Patty's Toxicology

Patty's Toxicology

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Chronic exposure to methyl isobutyl ketone (MIBK) can cause kidney and liver damage, with potential carcinogenic effects in both rats and mice.

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Proposed Occupational Exposure Limits for Non-Carcinogenic Hanford Waste Tank Vapor Chemicals

This study developed a procedure for assigning Acceptable Occupational Exposure Limits (AOELs) for non-carcinogenic Hanford waste tank vapor chemicals, providing guidelines for workers exposed to these chemicals.

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The Role of Metabolism in Establishing Chemical-Specific Adjustment Factors for n-Hexane and Methyl n-Butyl Ketone

The metabolic induction of toxicity of n-hexane and MBK by MEK should be considered in establishing chemical-specific adjustment factors for their use in adhesives.

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Use of partition models to evaluate guidelines for mixtures of volatile organic compounds.

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