Abstract Syntheses of fluorinated 8-ethoxy/fluoro-2-carboxy-4-substituted ary-2,3-dihydro1,5-benzothiazepines having substitutents as chloro, methyl and trifluoromethyl have been achieved by the reaction of 5-ethoxy/-fluoro-2-aminobenzenethiols with fluorinated 3-substituted benzoyl-2-propenoic acids in toluene with catalytic amount of trifluoroacetic acid. The progress of the reactions was monitored by t.1.c. studies. Structures of the title compounds are established by IR, PMR and mass spectral studies and microestimation data of nitrogen.

Fluorinated 8-ethoxy/fluoro-2-carboxy-4-(fluorinated aryl) -2,3-dihydro-1,5-benzothiazepines show potential as cardiovascular agents by synthesis with chloro, methyl, and trifluoro

Phosphorus Sulfur and Silicon and The Related Elements

SYNTHESES OF 1,5-BENZOTHIAZEPINES, PART XVI: SYNTHESES OF 8-ETHOXY/FLUORO-2-CABOXY-4-(FLUORINATED ARYL) -2,3-DIHYDRO-1,5-BENZOTHIAZEPINESAS PROSPECTIVE CARDIOVASCULAR AGENTS

Paper

SYNTHESES OF 1,5-BENZOTHIAZEPINES, PART XVI: SYNTHESES OF 8-ETHOXY/FLUORO-2-CABOXY-4-(FLUORINATED ARYL) -2,3-DIHYDRO-1,5-BENZOTHIAZEPINESAS PROSPECTIVE CARDIOVASCULAR AGENTS

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