Syntheses and anti-depressant activity of 5-amino-1, 3, 4-thiadiazole-2-thiol imines and thiobenzyl derivatives.

doi:10.1016/j.bmc.2008.07.056

Paper

DOI: 10.1016/j.bmc.2008.07.056

Syntheses and anti-depressant activity of 5-amino-1, 3, 4-thiadiazole-2-thiol imines and thiobenzyl derivatives.

Published Sep 1, 2008 · Mohammad Yusuf, R. Khan, B. Ahmed

Bioorganic & medicinal chemistry

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130

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Abstract

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In Vitro Study

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Two new imine derivatives of 5-amino-1,3,4-thiadiazole-2-thiol show significant anti-depressant activity, reducing immobility time by 77.99% and 76.26% compared to imipramine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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