Paper

Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands.

Published Jun 15, 2010 · Tao Li, W. Bunnelle, K. Ryther

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

2,5-diazabicyclo[2.2.1]heptanes show potential as potent alpha7 neuronal nicotinic receptor agonists, with the 5-N-methyl substituent, heteroaryl linker, and terminal aryl group being critical for activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands.

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