Syntheses of substituted 2,4-dioxo-thienopyrimidin-1-acetic acids and their evaluation as aldose reductase inhibitors

doi:10.1016/0223-5234(93)90112-R

Paper

DOI: 10.1016/0223-5234(93)90112-R

Syntheses of substituted 2,4-dioxo-thienopyrimidin-1-acetic acids and their evaluation as aldose reductase inhibitors

Published 1993 · K. Ogawva, I. Yamawaki, Yi Matsusita

European Journal of Medicinal Chemistry

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Abstract

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In Vitro Study

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Substituted 2,4-dioxo-thienopyrimidin-1-acetic acids with benzyl moiety at the N-3 position show potent aldose reductase inhibitory activity, with some showing moderate in vivo activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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How and Why a Protic Ionic Liquid Efficiently Catalyzes Chemical Fixation of CO2 to Quinazoline-2,4-(1H,3H)-Diones: Electrostatically Controlled Reactivity.

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