Synthesis of 1-(4-chloro-phenyl)-4,4-dimethyl-pentan-3-one

Paper

Synthesis of 1-(4-chloro-phenyl)-4,4-dimethyl-pentan-3-one

Published 2007 · Shen De-long

Journal of Zhejiang University of Technology

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Abstract

Using 4-chlorophenyl aldehyde and 3,3-Dimethyl-2butanone as raw materials,1-(4-Chloro-phenyl)-4,4-dimethyl-pentan-3-one was synthesized by condensation and hydrogenation processes.The yield of 1-(4-Chloro-phenyl)-4,4-dimethyl-pent-1-en-3-one can be reached 98.3% with the purity of 97.4%(GC) by using strongly basic ion exchange resin and CO2.By regulating value of pH and using flux such as N,N-dimethyl formamide,the dechloridizing byproduct was reduced,and the yield of 1-(4-Chloro-phenyl)-4,4dimethyl-pentan-3-one can be reached 98% with the purity 98.7%(GC).Economic and technical indices of the above synthetic method are more favorable than those previously reported.

Study Snapshot

This study presents a more efficient method for synthesizing 1-(4-chloro-phenyl)-4,4-dimethyl-pentan-3-one using 4-chlorophenyl aldehyde and 3,3-Dimethyl-2butanone, achieving higher yields and

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis of 1-(4-chloro-phenyl)-4,4-dimethyl-pentan-3-one

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