Paper
Synthesis of 1-Cyanobenzimidazole Derivatives and Their Effect on Rat Erythrocyte Resistance
Published Aug 1, 2002 · P. P. Purygin, L. I. Sergeeva, V. E. Kuz’mina
Pharmaceutical Chemistry Journal
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Abstract
Benzimidazole derivatives are capable of increasing the nonspecific resistance of the organism to the action of unfavorable factors [1]. Previously [2, 3], we studied leukocyte reactions induced by 1-cyanobenzimidazole in experimental animals. Here we report on the effect of 1-cyanobenzimidazole (I), 6-nitro-1-cyanobenzimidazole (II), and 1-(4-nitrophenyloxy-[Z,E ]-carbimino)-6-nitrobenzimidazole (III) on the resistance of erythrocytes.
Non-RCT
Animal Study1-Cyanobenzimidazole derivatives increase rat erythrocyte resistance to unfavorable factors, suggesting their potential use in pharmacological studies.
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