A novel synthesis of diversely substituted 2,2'-biphenols through Pd(ii)-catalyzed, (t)BuOOH-oxidized, and hydroxyl-directed C(sp(2))-H hydroxylation of [1,1'-biphenyl]-2-ols has been developed. Notably, this finding is distinct from previous reports in which [1,1'-biphenyl]-2-ols underwent an intramolecular C-H activation and C-O bond formation to afford dibenzofurans under the promotion of Pd(ii) but in the absence of (t)BuOOH.

This novel synthesis of 2,2'-biphenols through Pd(ii)-catalyzed, (t)BuOOH-oxidized, and hydroxyl-directed C(sp(2))-H hydroxylation of [1,1'-biphenyl]-2-ol

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Synthesis of 2,2'-biphenols through direct C(sp(2))-H hydroxylation of [1,1'-biphenyl]-2-ols.

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