An efficient method for the synthesis of 4,5-disubstituted 2-aminofuran-3-carbonitriles via a cascade Stetter―γ-ketonitrile cyclization reaction of aromatic aldehydes with acylidenemalononitriles, catalyzed by N-heterocyclic carbenes, has been developed. This procedure provides the corresponding products in moderate to high yields under mild conditions.

This efficient method for synthesis of 4,5-disubstituted 2-aminofuran-3-carbonitriles using a cascade Stetter--ketonitrile cyclization reaction provides moderate to high yields under mild conditions.

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An Efficient Synthesis of 2-Aminofuran-3-carbonitriles via Cascade Stetter― γ-Ketonitrile Cyclization Reaction Catalyzed by N-Heterocyclic Carbene

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