A facile and efficient synthesis of 2-bromo-5-methyl pyrazine is described. The synthetic scheme involves the conversion of 5-methylpyrazine-2-carboxylic acid to the corresponding amide which on Hofmann degradation gives the amine compound. This amine compound on diazotization followed by in-situ bromination produces the targeted 2-bromo-5-methyl pyrazine.

The efficient synthesis of 2-bromo-5-methyl pyrazine involves the conversion of 5-methylpyrazine-2-carboxylic acid to the amide compound, followed by diazotization and in-situ bromination to produce the targeted compound.

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An efficient and facile synthesis of 2-bromo-5-methylpyrazine

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