[Synthesis of 2-methoxynaphthalene derivatives as potential anti-inflammatory agents].

doi:10.1002/chin.198234159

Paper

[Synthesis of 2-methoxynaphthalene derivatives as potential anti-inflammatory agents].

Published Mar 1, 1982 · Cavrini, P. Roveri, Rita Gatti

Il Farmaco; edizione scientifica

UNKNOWN SJR score

5

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0

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Abstract

Compounds having 2-methoxynaphthalene as their parent nucleus were synthesized and evaluated for antiinflammatory effect according to the carrageenin paw edema method in rats. The synthetic routes for the preparation of isomeric 1,2- and 2,6-disubstituted derivatives are described. Replacement of the alpha-methylacetic moiety in naproxen by 4-hydroxybutyric acid side chain did not cause loss of activity.

Non-RCT

Animal Study

Study Snapshot

2-methoxynaphthalene derivatives show potential as anti-inflammatory agents, with 1,2- and 2,6-disubstituted derivatives showing no loss of activity when replacing the alpha-methylacetic moiety in naproxen with 4-hydroxybutyric acid side chain.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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[Synthesis of 2-methoxynaphthalene derivatives as potential anti-inflammatory agents].

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