2,2-Dimethyl-5-((phenylamino)methylene)-1,3-dioxane-4,6-dione, prepared by the reaction of Meldrum’s acid with triethyl orthoformate and aniline, reacts with active methylene nitriles to afford 2-oxo-1,2-dihydropyridine-3-carboxylic acid derivatives, which are useful as drug precursors or perspective ligands.

This study presents a novel method for synthesizing 2-oxo-1,2-dihydropyridine-3-carboxylic acid derivatives, useful as drug precursors or perspective ligands, using Meldrum's acid and active methylene nitriles.

Paper

Synthesis of New 2-Oxo-1,2-Dihydropyridine-3-Carboxylic Acid Derivatives

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