Synthesis of New 2-Oxo-1,2-Dihydropyridine-3-Carboxylic Acid Derivatives

doi:10.3390/ecsoc-23-06523

Paper

Synthesis of New 2-Oxo-1,2-Dihydropyridine-3-Carboxylic Acid Derivatives

Published Nov 14, 2019 · V. Dotsenko, A. A. Russkih, N. A. Aksenov

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Abstract

2,2-Dimethyl-5-((phenylamino)methylene)-1,3-dioxane-4,6-dione, prepared by the reaction of Meldrum’s acid with triethyl orthoformate and aniline, reacts with active methylene nitriles to afford 2-oxo-1,2-dihydropyridine-3-carboxylic acid derivatives, which are useful as drug precursors or perspective ligands.

Study Snapshot

This study presents a novel method for synthesizing 2-oxo-1,2-dihydropyridine-3-carboxylic acid derivatives, useful as drug precursors or perspective ligands, using Meldrum's acid and active methylene nitriles.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of New 2-Oxo-1,2-Dihydropyridine-3-Carboxylic Acid Derivatives

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References

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Pyridone carboxylic acids can reduce drug adsorption in the intestines by forming aluminum complexes with metallic antacids, such as aluminum hydroxide and magnesium oxide.

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