Synthesis of 3,3-Dimethoxypropanenitrile

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Synthesis of 3,3-Dimethoxypropanenitrile

Published 2005 · Jiang Jian-quan

Dyestuffs and coloration

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Abstract

3, 3-Dimethoxypropanenitrile was synthesized from 2-chloro-3-phenylsulfonylpropanenitrile by elimination and addition reactions. 3-phenylsulfonylpropanenitrile was obtained by eliminating HCl from 2-chloro-3-phenylsulfonylpropanenitrile at 0-20℃ with a yield of 88%. 3-Phenylsulfonylpropanenitrile was reacted with sodium methoxide in methanol, giving 3, 3-dimethoxypropanenitrile with a yield of 98%. Elimination reaction was innovated by using THF as a solvent instead of ethyl ether and addition reaction was innovated by using an excess of sodium methoxide in methanol, so as to have the reaction condition optimized.

Study Snapshot

This study demonstrates a 98% yield of 3,3-dimethoxypropanenitrile from 2-chloro-3-phenylsulfonylpropanenitrile using THF as a solvent and optimizing the reaction conditions using sodium methoxide in methanol.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis of 3,3-Dimethoxypropanenitrile

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