Paper
SYNTHESIS OF 3,4,5-TRIMETHOXYBENZALDEHYDE
Published Sep 1, 1990 · P. Manchand, Peter S. Belica, Harry S. Wong
Synthetic Communications
16
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Influential Citations
Abstract
Abstract The copper [I]-catalyzed exchange of bromine by methoxide in 5-bromovanillin and in 3,5-dibromo-4-hydroxybenzaldehyde provides an efficient method for preparing 3,5-dimethoxy-4-hydroxybenzaldehyde, from which 3,4,5-trimethoxybenzaldehyde is obtained by methylation with dimethylsulfate.
Copper [I]-catalyzed exchange of bromine by methoxide in 5-bromovanillin and 3,5-dibromo-4-hydroxybenzaldehyde efficiently prepares 3,5-dimethoxy-4-hydroxybenzaldehyde, which is then methylated with di
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