3,5-bis(trifluoromethyl)benzoyl chloride,as an important drug intermediate,was synthesized by 1,3-bis(trifluoromethyl)benzene with the total yield of 61.7% in three steps including bromination,carboxylation and chlorination.The effects of the amount of sulfuric acid used and the reaction temperature on bromination were discussed.The effects of the amount of dimethyl sulfoxide used and the reaction temperature on chlorination were also investigated.The suitable condition for synthesizing 3,5-bis(trifluoromethyl)benzoyl chloride was obtained.The results show that this simple technique had many advantages such as higher economic value.

This study successfully synthesized 3,5-bis(trifluoromethyl)benzoyl chloride using 1,3-bis(trifluoromethyl)benzene, achieving a yield of 61.7% and offering higher economic value.

Paper

Synthesis of 3,5-Bis(Trifluoromethyl)Benzoyl Chloride

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