Synthesis of 3,5-Di-tert-butyl-4-hydroxybenzoic Acid

Paper

Synthesis of 3,5-Di-tert-butyl-4-hydroxybenzoic Acid

Published 2003 · Lai Yi

Chinese Journal of Pharmaceuticals

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1

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Abstract

3,5-Di- tert -butyl-4-hydroxybenzoic acid was synthesized in 63.7% overall yield by treatment of 2,6-di- tert -butyl-4-methylphenol with bromine in acetic acid to give 3,5-di- tert -butyl-4-hydroxy- benzaldehyde which underwent oxidization by Jones reagent.

Study Snapshot

3,5-Di-tert-butyl-4-hydroxybenzoic acid can be synthesized in a 63.7% overall yield by treating 2,6-di-tert-butyl-4-methylphenol with bromine in acetic acid, yielding 3,5-di-tert-but

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of 3,5-Di-tert-butyl-4-hydroxybenzoic Acid

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References

Citations

Synthesis, Characterization, and In Vitro Cytotoxicity of Triorganotin 3,5-Di-tert-butyl-4-hydroxybenzoates

Triorganotin 3,5-di-tert-butyl-4-hydroxybenzoates show higher in vitro cytotoxicity against human tumor cell lines A549 than cis-platin, offering potential as a new cancer drug.