New 3-amino-5-arylpyridazine-4-carbonitriles have been synthesized by a one-pot three-component reaction of malononitrile with arylglyoxals in the presence of hydrazine hydrate at room temperature in water and ethanol. KEYWORDS  Arylglyoxals, arylpyridazines, hydrazine hydrate, one-pot, malononitrile.

A one-pot three-component reaction of malononitrile, arylglyoxals, and hydrazine hydrate allows for the synthesis of 3-amino-5-arylpyridazine-4-carbonitriles at room temperature in water and ethanol.

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A simple three-component synthesis of 3-amino-5-arylpyridazine-4-carbonitriles

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