SYNTHESIS OF 3-METHYLISOXAZOLE- 5-CARBOXAMIDES AND 5-[(1H-PYRAZOL-1-YL)CARBONYL]- 3-METHYLISOXAZOLES

doi:10.1081/SCC-120002127

Paper

SYNTHESIS OF 3-METHYLISOXAZOLE- 5-CARBOXAMIDES AND 5-[(1H-PYRAZOL-1-YL)CARBONYL]- 3-METHYLISOXAZOLES

Published Jan 1, 2002 · M. Martins, Marcelo Neto, A. Sinhorin

Synthetic Communications

Q3 SJR score

15

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0

Influential Citations

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Abstract

ABSTRACT The one-pot synthesis of six 3-methylisoxazole-5-carboxamides 2 [where the N-substituents are R1 = H, Me and R2 = Ph, CH2Ph, n-Bu, C(CH3)2Et, 3-methylisoxazol-5-yl] and twelve 5-[(1H-pyrazol-1-yl)carbonyl]-3-methyl isoxazoles 3 and 4 [where the pyrazole substituents are R3 (C5/C3) = CO2Et, CF3 and R5 (C3/C5) = H, Me, Et, Ph] from the 3-methyl isoxazole-5-carboxylic acid, thionyl chloride and the corresponding amine or pyrazole is reported. In the synthesis of 5-[(1H-pyrazol-1-yl)carbonyl]-3-methylisoxazoles we obtained a mixture of 1,3- and 1,5-isomers 3 and 4 in variable ratios, i.e., the substituent R3 (CO2Et and CF3) are present in position 3 or 5 on the pyrazole ring.

Study Snapshot

This study presents a one-pot synthesis of 3-methylisoxazole-5-carboxamides and 5-[(1H-pyrazol-1-yl)carbonyl]-3-methyl isoxazoles, resulting in a mixture of 1,3- and 1,5-isomers in variable

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

SYNTHESIS OF 3-METHYLISOXAZOLE- 5-CARBOXAMIDES AND 5-[(1H-PYRAZOL-1-YL)CARBONYL]- 3-METHYLISOXAZOLES

References

Citations

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Ultrasound-promoted synthesis of 5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles and beta-enamino trihalomethyl ketones in water provides a convenient method for preparing these compounds.

One‐Pot Synthesis of Pyrazole‐5(3)‐carboxyamides

This study demonstrates a convenient one-pot synthesis of eight pyrazole-5(3)-carboxyamides using 5(3)-trichloromethylpyrazoles with amines, demonstrating the trichloromethyl group as a convenient precursor to carboxyamide groups.

Synthesis of new halo-containing acetylenes and their application to the synthesis of azoles

This study demonstrates the efficient synthesis of halo- and isoxazole-containing acetylenes and their application in the synthesis of azoles.

Regiospecific synthesis of polyfluorinated heterocycles

Polyfluorinated heterocycles can be synthesized in moderate to good yields under mild conditions using various dinucleofiles.

Haloacetylated enol ethers: 18

This study presents a convenient method for synthesizing alkyl 6-[4,5-dihydroisoxazol-3-yl(-pyrazol-3(5)-yl)]hexanoates from methyl 10,10,10-trifluoro[chloro]-9-ox