Reaction of 2-phenyl-4H-1-benzothiopyran-4-ones and related compounds with chloromethyl methyl ether and fuming sulfuric acid gave mainly 3-chloromethyl compound, whereas chloromethylation of methoxy-substituted thioflavones took place at another position or gave tris(chloromethyl) compound. 3-(Chloromethyl)thioflavone could be easily converted into various 3-(substituted methyl)thioflavones which showed significant antimicrobial activity against Trichophytons.

3-(Substituted Methyl)-2-phenyl-4H-1-benzothiopyran-4-ones show significant antimicrobial activity against Trichophytons, making them promising candidates for pharmaceutical applications.

Paper

Synthesis of 3-(Substituted Methyl)-2-phenyl-4H-1-benzothiopyran-4-ones

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