A novel synthesis of 3-substituted 4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with primary amines has been developed. Under mild reaction conditions, the products were achieved in good yield from commercially available starting materials.

This novel synthesis of 3-substituted 4(3H)-quinazolinones using HATU-mediated coupling of 4-hydroxyquinazolines with primary amines provides a promising method for synthesis of novel pharmaceuticals.

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Synthesis of 3-substituted-4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with amines.

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