4-Amino-2-(trifluoromethyl)benzonitrile,an intermediate for the synthesis of bicalutamide,was synthesized from m-fluoro-(trifluoromethyl)benzene via bromination,Grignard reaction,cyanidation and amination in overall yield of 49.2%.Its structure was confirmed by MS,IR and 1H NMR.In summary,an environmentally friendly practical method has been developed.

This study developed an environmentally friendly, practical method for synthesizing 4-Amino-2-(trifluoromethyl)benzonitrile, an intermediate for bicalutamide, with a yield of 49.2%.

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Synthesis of 4-Amino-2-(trifluoromethyl)benzonitrile-an Intermediate for Bicalutamide

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