4-benzyloxy-2-methoxybenzaldehyde was synthesized from 3-methoxyphenol via O-alkylation reaction and Vilsmeier-Hack(V-H) reaction.The overall yield of the target product was 82.26%.The optimum reaction conditions were as follows:the catalyst was TBAB;reaction time was 3 h;n(m-benzyloxyanisole)∶n(DMF)∶ n(POCl3)=1∶1.5∶2;V-H reaction temperature was 70—75℃;synthesized V-H reagent time was 1.5 h;the holding time was 3 h.

The synthesis of 4-benzyloxy-2-methoxybenzaldehyde from 3-methoxyphenol using TBAB catalyst and optimal reaction conditions yielded 82.26% of the target product with a yield of 82.26%.

Paper

Synthesis of 4-Benzyloxy-2-Methoxybenzaldehyde

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