SYNTHESIS OF 5-(4'-AROYL)-ARYLOXY METHYL-4H-(1,2,4)-TRIAZOLIN-3-THIOL AND THEIR BIOLOGICAL ACTIVITY

doi:10.1515/HC.2004.10.1.85

Paper

SYNTHESIS OF 5-(4'-AROYL)-ARYLOXY METHYL-4H-(1,2,4)-TRIAZOLIN-3-THIOL AND THEIR BIOLOGICAL ACTIVITY

Published 2004 · B. Sudha, S. Shashikanth, S. Ara Khanum

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Abstract

5-(4'-aroyl)-aryloxy methyl-4H-1,2, 4)-triazolin-3-thiols were synthesized by using substituted phenyl benzoates as the starting material. Phenyl benzoates on Fries rearrangement gave p-hydroxy benzophenones which on treatment with ethyl bromoacetate in presence of anhydrous potassium carbonate and dry acetone gave corresponding benzoyl phenyloxy esters in excellent yield. Esters were refluxed with thiosemicarbazide in presence of acetic anhydride gave cyclized title compounds. Supports for the structures of the synthesized compounds have been provided by their elemental analysis and spectral data. The newly synthesized compounds were screened for antibacterial and antifungal activities. Key words: Aroyl aryloxy esters, triazolin-3-thiols.

Study Snapshot

5-(4'-aroyl)-aryloxy methyl-4H-1,2,4-triazolin-3-thiols show promising antibacterial and antifungal activities when synthesized using substituted phenyl benzoates.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

SYNTHESIS OF 5-(4'-AROYL)-ARYLOXY METHYL-4H-(1,2,4)-TRIAZOLIN-3-THIOL AND THEIR BIOLOGICAL ACTIVITY

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