Five 5–aryl-substituted-3-hydroxy-isoxazoles were synthesized from aromatic aldehydes by means of wittig reaction,bromide reaction,and cyclization.All of the target compounds have been confirmed by 1H NMR,MS spectrums and elementary analysis.In addition,the possible mechanism of wittig reaction and the cyclization route was discussed.

5-aryl-substituted-3-hydroxy-isoxazoles were synthesized from aromatic aldehydes using the wittig reaction, bromide reaction, and cyclization, with confirmed 1H NMR, MS spectrum, and elementary analysis.

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Synthesis of 5-aryl-substituted-3-hydroxy-isoxazoles

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