Paper

Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.

Published Aug 1, 2012 · F. Hansen, M. Khankischpur, I. Tolaymat

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives show promising in vitro activity as dual 5-LOX/COX inhibitors with submicromolar IC50 values for 5-LOX and COX-1 inhibition.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.

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