The interaction of tetraphenylphthalic anhydride with o-chlorotoluene under Friedel-Craft condition gives 2-(4-chloro-3-methyl)benzoyl-3,4,5,6-tetraphenyl benzoic acid(1), which on reaction with hydrazine derivatives gave phthalazinones (2a-d). The behaviour of (2a) towards carbon electrophiles and carbon nucleophiles has been investigated. The chlorophthalazinones (4a) also has been synthesized from the action of on (2a). The behaviour of (4a) towards nitrogen, and oxygen nucleophiles also have been described.

This study demonstrates the synthesis of 4, 5, 6, 7-tetraphenyl-8-(substituted)-3 (2H)-phthalazinone derivatives likely to possess antihypertensive activity by utilizing tetraphenylphthalic anhydride and o-chlor

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Synthesis of 4, 5, 6, 7-Tetraphenyl-8-(substituted)-3 (2H)-phthalazinone Derivatives Likely to Posses Antihypertensive Activity

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