Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cyclohepten-5-one is an important intermediate of loratadine.It was synthesized from 2-cyano-3-methylpyridine as the starting material via Ritter reaction, alkylation, cyanidation, hydrolysis and cyclization under mild conditions. The total yield attained was 25.6%. The chemical structure was confirmed by means of 1 H-NMR,MS and m.p.data.

8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cyclohepten-5-one was successfully synthesized from 2-cyano-3-methylpyridine under mild conditions, providing an intermediate for loratadine production.

Paper

Synthesis of 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo [a,d] cyclohepten-5-one

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