Paper

Synthesis of 8-hydroxyquinoline glycoconjugates and preliminary assay of their β1,4-GalT inhibitory and anti-cancer properties.

Published Mar 1, 2019 · M. Krawczyk, G. Pastuch-Gawołek, A. Mrozek-Wilczkiewicz

Bioorganic chemistry

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Abstract

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In Vitro Study

Study Snapshot

8-hydroxyquinoline glycoconjugates show potential in inhibiting 1,4-GalT enzyme and inhibiting cancer cell proliferation, with their activity and bioavailability influenced by the type of attached sugar, protecting groups, and linker between sugar and quinolone aglycone.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis of 8-hydroxyquinoline glycoconjugates and preliminary assay of their β1,4-GalT inhibitory and anti-cancer properties.

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