Synthesis of some new 1,6-dihydro-3-substituted-6-spiro-(9'-fluorene)-1,2,4-triazin-5-( 4H)-on es as potential anti HIV and anticancer drugs.

doi:10.1002/CHIN.199512225

Paper

Synthesis of some new 1,6-dihydro-3-substituted-6-spiro-(9'-fluorene)-1,2,4-triazin-5-( 4H)-on es as potential anti HIV and anticancer drugs.

Published Jun 1, 1994 · R. M. Abdel-Rahman, M. Seada, M. Fawzy

Bollettino chimico farmaceutico

UNKNOWN SJR score

8

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0

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Abstract

1,6-Dihydro-3 (2H)-thioxo-6-spiro-(9'-fluorene)-1,2,4-triazin-5(4H)-one (1) has been used to synthesize several analogous compounds via nucleophilic substitution reactions. Spectroscopic data are given in support of the proposed structures. Some of the new products possessed good anti HIV and anticancer activities.

Study Snapshot

New 1,6-dihydro-3-substituted-6-spiro-(9'-fluorene)-1,2,4-triazin-5-(4H)-ones show potential as anti HIV and anticancer drugs.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of some new 1,6-dihydro-3-substituted-6-spiro-(9'-fluorene)-1,2,4-triazin-5-( 4H)-on es as potential anti HIV and anticancer drugs.

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References

Citations

Heterocyclic Compounds Bearing Triazine Scaffold and Their Biological Significance: A Review.

Triazine nucleus is an interesting core moiety for researchers to develop future drugs with diverse biological activities, including antibacterial, antifungal, anti-cancer, and antiviral properties.

Synthetic Strategies, Chemical Reactivities and Biological Activities of 3-Thioxo-1,2,4-Triazin-5-Ones and Their Derivatives

Synthesis of 3-thioxo-1,2,4-triazin-5-ones and their derivatives has shown promising results in anticancer, anti-HIV, antimicrobial, and enzymatic applications.

An efficient and facile synthesis of new tetracyclic fused pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolin-4(5H)-ones

This study demonstrates an efficient and facile synthesis of novel tetracyclic fused pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolin-4(5H)-ones using a Michael addition reaction followed by intramolecular cycl

Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent

This study successfully synthesized novel pyrimido[5,4-e][1,2,4]triazines and pyrazolopyrimidines using DMF-DMA, which showed promising antitumor activity against human lung carcinoma (A549).

An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy

This one-pot method allows for the synthesis of polynuclear dispiroheterocyclic structures with five stereogenic centers using azomethine ylides generated in situ from isatin derivatives and sarcosine.