Synthesis of carbocyclic and heterocyclic β-aminocarboxylic acids.

doi:10.1021/cr300454h

Paper

Synthesis of carbocyclic and heterocyclic β-aminocarboxylic acids.

Published Jan 22, 2014 · L. Kiss, F. Fülöp

Chemical reviews

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Abstract

In consequence of their biological e ff ects, conformationally constrained carbocyclic β -amino acids have generated great interest among synthetic and medicinal chemists in the past 2 decades, and they have become a hot topic in organic and bioorganic chemistry. These compounds are found in natural products and antibiotics. They are also considered important precursors for pharmacologically interesting β -lactams and other bioactive compounds. Certain carbocyclic β -amino acids, e.g., cispentacin , icofungipen , and BAY Y9379 , possess noteworthy antifungal or antibacterial activities, while tilidin , a phenyl-substituted cyclohexene amino ester, is an analgetic.

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Carbocyclic -amino acids are important precursors for pharmacologically interesting -lactams and other bioactive compounds, with potential applications in antifungal, antibacterial, and analgesic fields.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of carbocyclic and heterocyclic β-aminocarboxylic acids.

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References

Citations

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