Synthesis and acrosin inhibitory activities of substituted ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives.

doi:10.1016/j.bmcl.2011.07.110

Paper

Synthesis and acrosin inhibitory activities of substituted ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives.

Published Oct 1, 2011 · Jingjing Qi, Ju Zhu, Xuefei Liu

Bioorganic & medicinal chemistry letters

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9

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Abstract

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In Vitro Study

Study Snapshot

Novel ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives show potent acrosin inhibitory activities, offering a new structural type for developing novel contraceptive acrosin inhibitory agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and acrosin inhibitory activities of substituted ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives.

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