Abstract Fourteen 1H-pyrazole-5-carboxylic acid derivatives containing oxazole and thiazole rings were synthesized and characterized by 1H NMR, mass spectrometry and elemental analysis. Most target compounds were obtained in overall yields in the range of 30–50%. The insecticidal activities of these new compounds against Aphis fabae were evaluated. The bioassays’ results indicate that some of these compounds exhibit good activities, especially compound 7h which shows 85.7% mortality against A. fabae at a concentration of 12.5 mg/L. This activity is comparable to that of the commercial insecticide imidacloprid.

Novel 1H-pyrazole-5-carboxylic acid derivatives show good insecticidal activities against Aphis fabae, with compound 7h showing 85.7% mortality at 12.5 mg/L, comparable to imidacloprid.

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Synthesis and insecticidal activities of novel 1H-pyrazole-5-carboxylic acid derivatives

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