Synthesis and pharmacological activities of some pyrido[2,1-b]oxazines

doi:10.1016/0223-5234(92)90187-6

Paper

DOI: 10.1016/0223-5234(92)90187-6

Synthesis and pharmacological activities of some pyrido[2,1-b]oxazines

Published Aug 1, 1992 · A. S. Feliciano, E. Caballero, P. Puebla

European Journal of Medicinal Chemistry

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Abstract

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Study Snapshot

Pyrido[2,1-b]oxazines show long-term antihypertensive-bradycardic effects, anti-inflammatory, spasmolytic, and other pharmacological properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/S0040-4020(01)86577-7

2,3,8,8a-Tetrahydro-7H-oxazolo[3,2-a]pyridine : a new heterocyclic system

This study successfully synthesized a new heterocyclic system by reacting,-unsaturated ketones or aldehydes with N-hydroxyethyl-enamines of acetoacetate esters, resulting in 1,4-dihydropyridines, aminocycl

1991·13citations·A. S. Feliciano et al.·Tetrahedron

Tetrahedron

DOI: 10.1016/0014-2999(80)90365-9

Different antihypertensive effects of nifedipine in conscious experimental hypertensive and normotensive rats.

Nifedipine has a more selective antihypertensive effect in hypertensive rats than in normotensive rats, likely due to a different affinity for calcium ion in vascular smooth muscle.

1980·76citations·H. Ishii et al.·European journal of pharmacology

European journal of pharmacology

DOI: 10.1016/0014-2999(73)90012-5

Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone.

Indomethacin and oxyphenbutazone cause gastric ulcers in albino rats, which can be reduced by pretreatment with certain drugs, but imipramine increases their incidence.

1973·165citations·K. Bhargava et al.·European journal of pharmacology

European journal of pharmacology

DOI: 10.1016/s0022-3565(25)26625-3

ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDOMETHACIN, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID.

Indomethacin is a potent anti-inflammatory and antipyretic compound with 85 times the potency of phenylbutazone and 4 times that of hydrocortisone.

1963·369citations·C. Winter et al.·The Journal of pharmacology and experimental therapeutics

The Journal of pharmacology and experimental therapeutics

DOI: 10.1111/j.2042-7158.1957.tb12290.x

A NEW SERIES OF POTENT ANALGESICS

The analgesic activity of these compounds depends on the nature of substituent R, with the most potent activity predominating in compounds with a COC,H, substituent.

1956·197citations·P. Janssen et al.·Journal of Pharmacy and Pharmacology

Journal of Pharmacy and Pharmacology

Citations

DOI: 10.1016/j.molstruc.2024.139514

Effective scaffolds as antihypertensive agents, a long story with happy endings; a review tracing the promising reported candidates

Heterocyclic-based molecules have been effective in designing, synthesizing, and screening new antihypertensive candidates from 1968 to 2024, with promising results in vivo and in vitro evaluations.

2024·0citations·Marian W. Aziz et al.·Journal of Molecular Structure

Journal of Molecular Structure

DOI: 10.1016/j.tetlet.2021.153431

Uniquely functionalized tetrahydropyrido[2,1-b][1,3]oxazines: Diastereoselective 1:2 assembly from pyridines with oxalylacetylenes

This study demonstrates a facile, one-pot method for assembling functionalized tetrahydropyrido[2,1-b][1,3]oxazines with oxalylacetylenes, mainly as 2S ,9a S -diastere

2021·5citations·K. Belyaeva et al.·Tetrahedron Letters

Tetrahedron Letters

DOI: 10.1080/00397911.2019.1643889

Chemistry of bicyclic 5-6 systems: Synthesis of oxazolo[3,2-a]pyridines and their salts with a ring-junction nitrogen atom

Oxazolo[3,2-a]pyridines can be synthesized with high yields using readily accessible starting materials and efficient synthetic routes, resulting in enantiopure heterocycles and unexpected products.

2019·12citations·M. Monier et al.·Synthetic Communications

Synthetic Communications

DOI: 10.1021/acscombsci.8b00076

Polymer-Supported Syntheses of Heterocycles Bearing Oxazine and Thiazine Scaffolds.

Solid-phase synthesis is a versatile method for preparing diverse compounds with oxazine and thiazine scaffolds, with recent contributions focusing on stereoselective morpholine syntheses.

2018·11citations·P. Králová et al.·ACS combinatorial science

ACS combinatorial science

DOI: 10.1080/00304948.2018.1462077

Facile Diastereoselective Synthesis of Functionalized Tetrahydropyridines Using Fe3O4/SiO2/TiO2 Nanocomposites

Diastereoselective synthesis of functionalized tetrahydropyridines using Fe3O4/SiO2/TiO2 nanocomposites is a rapid and efficient method for preparing biologically active compounds.

2018·4citations·N. Hazeri et al.·Organic Preparations and Procedures International

Organic Preparations and Procedures International

Synthesis and pharmacological activities of some pyrido[2,1-b]oxazines

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References

2,3,8,8a-Tetrahydro-7H-oxazolo[3,2-a]pyridine : a new heterocyclic system

This study successfully synthesized a new heterocyclic system by reacting,-unsaturated ketones or aldehydes with N-hydroxyethyl-enamines of acetoacetate esters, resulting in 1,4-dihydropyridines, aminocycl

Different antihypertensive effects of nifedipine in conscious experimental hypertensive and normotensive rats.

Nifedipine has a more selective antihypertensive effect in hypertensive rats than in normotensive rats, likely due to a different affinity for calcium ion in vascular smooth muscle.

Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone.

Indomethacin and oxyphenbutazone cause gastric ulcers in albino rats, which can be reduced by pretreatment with certain drugs, but imipramine increases their incidence.

ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDOMETHACIN, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID.

Indomethacin is a potent anti-inflammatory and antipyretic compound with 85 times the potency of phenylbutazone and 4 times that of hydrocortisone.

A NEW SERIES OF POTENT ANALGESICS

The analgesic activity of these compounds depends on the nature of substituent R, with the most potent activity predominating in compounds with a COC,H, substituent.

Citations

Effective scaffolds as antihypertensive agents, a long story with happy endings; a review tracing the promising reported candidates

Heterocyclic-based molecules have been effective in designing, synthesizing, and screening new antihypertensive candidates from 1968 to 2024, with promising results in vivo and in vitro evaluations.

Uniquely functionalized tetrahydropyrido[2,1-b][1,3]oxazines: Diastereoselective 1:2 assembly from pyridines with oxalylacetylenes

This study demonstrates a facile, one-pot method for assembling functionalized tetrahydropyrido[2,1-b][1,3]oxazines with oxalylacetylenes, mainly as 2S *,9a S *-diastere

Chemistry of bicyclic 5-6 systems: Synthesis of oxazolo[3,2-a]pyridines and their salts with a ring-junction nitrogen atom

Oxazolo[3,2-a]pyridines can be synthesized with high yields using readily accessible starting materials and efficient synthetic routes, resulting in enantiopure heterocycles and unexpected products.

Polymer-Supported Syntheses of Heterocycles Bearing Oxazine and Thiazine Scaffolds.

Solid-phase synthesis is a versatile method for preparing diverse compounds with oxazine and thiazine scaffolds, with recent contributions focusing on stereoselective morpholine syntheses.

Facile Diastereoselective Synthesis of Functionalized Tetrahydropyridines Using Fe3O4/SiO2/TiO2 Nanocomposites

Diastereoselective synthesis of functionalized tetrahydropyridines using Fe3O4/SiO2/TiO2 nanocomposites is a rapid and efficient method for preparing biologically active compounds.

This study demonstrates a facile, one-pot method for assembling functionalized tetrahydropyrido[2,1-b][1,3]oxazines with oxalylacetylenes, mainly as 2S ,9a S -diastere