In order to find new agents of antibacterial bis-biguanides with high antibacterial activities and low toxicity,five compounds of 1,6-di-(N5-phenyl-N1-diguanido) hexane dihydrochloride were designed and synthesized by the modified synthetic method reported in the literature according to biological isosterism,of which four compounds have not been reported until now.Compound structures were determined by IR,1 HNMR,and 13 CNMR.The biological activity tests show that some compounds have good antibacterial activity in vitro,and toxicity tests show that compounds have low toxicity.The structure-activity relationship was discussed.

1,6-di-(N5-phenyl-N1-diguanido) hexane dihydrochloride compounds show good antibacterial activity and low toxicity, offering potential for new antibacterial agents with high antibacterial activities and low toxicity.

Paper

Synthesis and in vitro antibacterial activity of 1,6-Di-(N~5-phenyl-N~1-diguanido) hexane dihydrochloride

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