Synthesis and biological activity of some 1-N-substituted 2-acetamido-2-deoxy-beta-D-glycopyranosylamine derivatives and related analogs.

doi:10.1016/S0008-6215(00)85318-5

Paper

DOI: 10.1016/S0008-6215(00)85318-5

Synthesis and biological activity of some 1-N-substituted 2-acetamido-2-deoxy-beta-D-glycopyranosylamine derivatives and related analogs.

Published 1980 · B. Paul, R. Bernacki, W. Korytnyk

Carbohydrate research

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Abstract

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In Vitro Study

Study Snapshot

1-N-substituted 2-acetamido-2-deoxy-beta-D-glycopyranosylamine derivatives show potential as metabolic inhibitors of cellular-membrane glycoconjugates, inhibiting growth of mouse cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis of 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-d-glucopyranosylamine and dimer formation

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Design, Synthesis, and Preliminary Biological Evaluation of GlcNAc‐6P Analogues for the Modulation of Phosphoacetylglucosamine Mutase 1 (AGM1/PGM3)

GlcNAc-6P analogues show potential in modulating AGM1/PGM3 activity, with a glycofused oxazoline analogue showing good inhibition and significant results in vitro.

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Sugar amino acid and use thereof

The invention provides an amino acid precursor that improves water solubility, stability in water, and bitterness properties while being converted into an amino acid in vivo.

2015·0citations·黒澤渉 et al.

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A novel strategy toward the synthesis of N -(β-glycosyl)asparagines based on the alkylation of ethyl nitroacetate using N -(β-glycosyl)iodoacetamides

This novel strategy successfully synthesizes N-(-glycosyl)asparagine precursors in good yield by alkylating ethyl nitroacetate with N-(-glycosyl)iodoacetamides, with diastereoselect

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Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins.

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