Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines.

doi:10.1016/J.BMCL.2007.10.027

Paper

Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines.

Published Jun 10, 2008 · P. Verhaeghe, N. Azas, M. Gasquet

Bioorganic & medicinal chemistry letters

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145

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

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Study Snapshot

New 4-aryl-2-trichloromethylquinazoline derivatives show promising antiplasmodial activity against Plasmodium falciparum, with potential for use in malaria treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines.

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References

Citations

One‐Pot Synthesis of Fused Isoxazolo[4′,5′:3,4]pyrrolo[2,1‐b] Quinazolines as Potent EGFR Targeting Anticancer Agents

Fused isoxazoles synthesized using a one-pot method show potential as potent EGFR targeting anticancer agents, showing superior activity against non-small-cell lung cancer cell lines compared to 5fluorouracil and erlotinib.

New Quinazolinone‐Tethered 1,2,3‐Triazoles aSs Potent Antimicrobial Agents: Design, Synthesis, Biological Evaluation and in silico Docking Study

Novel quinazolinone-linked 1,2,3-triazoles show promising antimicrobial activity and a favorable pharmacokinetic profile against various microorganisms.

Alternative and efficient one-pot three-component synthesis of substituted 2-aryl-4-styrylquinazolines/4-styrylquinazolines from synthetically available 1-(2-aminophenyl)-3-arylprop-2-en-1-ones: characterization and evaluation of their antiproliferative activities

This study presents a simple, efficient one-pot synthesis method for synthesizing 2-aryl-4-styrylquinazolines and (E)-4-styrylquinazolines, which show potent antitumor activity and low toxicity to normal human cell lines.

Visible-light-induced Cascade Radical Cyclization for the Synthesis of Amide-functionalized Fused Quinazolinones

Visible-light-induced cascade radical cyclization successfully synthesized 39 amide-functionalized fused quinazolinones with up to 88% yield, providing a mild and atom-economical method for diverse quinazolinone derivatives.

Recent Advances in Metal-Catalyzed Approaches for the Synthesis of Quinazoline Derivatives

Transition metal-catalyzed reactions have advanced new synthetic methods for quinazoline derivatives, offering potential for organic synthesis and medicinal chemistry applications.

Arene Ruthenium(II)-Catalyzed Sustainable Synthesis of 2,4-Disubstituted Quinazolines via Acceptorless Dual Dehydrogenative Coupling of Alcohols.

This study demonstrates an efficient and sustainable strategy for the direct synthesis of 2,4-disubstituted quinazolines by arene Ru(II)benzhydrazone complex, producing a maximum yield of 95% under mild reaction conditions.

Visible-light-promoted Photoredox-catalyzed N-Aminoalkylation of Quinazolinones with Simple Alkylamide

This study presents a metal-free, metal-free, and mild method for N-aminoalkylation of quinazolinones, yielding highly functionalized N-aminoalkyl quinazolinones with moderate to good yields and high chemoselectivity.