Paper

Synthesis and anti-proliferative activity of a small library of 7-substituted 5H-pyrrole [1,2-a][3,1]benzoxazin-5-one derivatives.

Published Jul 15, 2017 · Mariateresa Badolato, G. Carullo, Biagio Armentano

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

7-substituted 5H-pyrrolo[1,2-a][3,1]benzoxazin-5-one derivatives show promising anti-proliferative activity against human cancer cell lines, with apoptosis as a possible mechanism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and anti-proliferative activity of a small library of 7-substituted 5H-pyrrole [1,2-a][3,1]benzoxazin-5-one derivatives.

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