Various 9-substituted acridine derivatives, i.e., carbamic and thiocarbamic acid esters, urea, and thioureas, were synthesized and tested for potential biological activity. Some compounds were found active in antibacterial, metabolic, parasitologic, and GI screening procedures. The screening results indicate that acridine derivatives of these types possess biological activity similar to other known acridines, especially in the areas of antibacterial action and parasitology. The antisecretory action of one carbamate is a new potential use of acridines which has not been reported previously.

9-substituted acridine derivatives show potential biological activity, particularly in antibacterial action and parasitology, with one carbamate showing antisecretory action.

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Synthesis and biological activity of 9-substituted acridines.

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