Synthesis and hypoglycemic activity of phenylalkyloxiranecarboxylic acid derivatives.

doi:10.1021/JM00344A003

Paper

Synthesis and hypoglycemic activity of phenylalkyloxiranecarboxylic acid derivatives.

Published Feb 1, 1982 · K. Eistetter, H. Wolf

Journal of medicinal chemistry

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36

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0

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Abstract

A series of new 2-(phenylalkyl)oxirane-2-carboxylic acids has been synthesized and studied for its effects on the concentration of blood glucose. Most of the compounds exhibit remarkable blood glucose lowering activities in fasted rats. Structure-activity studies reveal that substituents like Cl or CF3 on the phenyl ring and a chain length of three to five carbon atoms lead to the most effective substances. Among these compounds, ethyl 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate (36) exhibits the most favorable activity.

Non-RCT

Animal Study

Study Snapshot

Phenylalkyloxiranecarboxylic acid derivatives show remarkable blood glucose lowering activities in fasted rats, with ethyl 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate (36) showing the most favorable

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and hypoglycemic activity of phenylalkyloxiranecarboxylic acid derivatives.

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References

Citations

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