A series of N-{(substituted)1,3-benzothiazol-2-yl}-1,1 '-biphenyl-4-carboxamides was synthesized by reaction between biphenyl acid chloride and 2-aminobenzothiazole. The synthesized compounds were screened in vivo for diuretic activity. Among the series, N-(1,3-benzothiazol-2-yl)-1,1'-biphenyl-4-carboxamide (II) was found to be the most promising candidate.

N-(1,3-benzothiazol-2-yl)-1,1'-biphenyl-4-carboxamide (II) shows promising diuretic activity in vivo, with potential applications in drug discovery.

Paper

Synthesis and in vivo diuretic activity of biphenyl benzothiazole-2-carboxamide derivatives.

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