Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines.

doi:10.1016/j.ejmech.2015.09.002

Paper

Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines.

Published Oct 20, 2015 · P. Marchand, M. Bazin, F. Pagniez

European journal of medicinal chemistry

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24

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Abstract

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In Vitro Study

Study Snapshot

Two imidazo[1,2-a]pyrazines show promising antileishmanial activity with low cytotoxicity against macrophages and 3T3 mouse fibroblast cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines.

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