Several thiophenecarboxylic acids and their derivatives are known to display bactericidal activity, including significant antituberculosis action [i]. Biological activity in many cases can be enhanced by the introduction of an aryl substituent [2-4]. In this context we have synthesized some derivatives of 5-arylthiophene-2-carboxylic acids by condensation of a series of 8-chloro-8-arylacroleins and evaluated their antimicrobial activity.

Derivatives of 5-arylthiophene-2-carboxylic acids show enhanced antimicrobial activity when introduced with an aryl substituent, potentially benefiting antituberculosis treatments.

Paper

Synthesis and biological activity of derivatives of 5-arylthiophene-2-carboxylic acids

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