Synthesis, antiproliferative activity evaluation and structure-activity relationships of novel aromatic urea and amide analogues of N-phenyl-N'-(2-chloroethyl)ureas.

doi:10.1016/j.ejmech.2010.03.018

Paper

Synthesis, antiproliferative activity evaluation and structure-activity relationships of novel aromatic urea and amide analogues of N-phenyl-N'-(2-chloroethyl)ureas.

Published Jul 1, 2010 · S. Fortin, E. Moreau, J. Lacroix

European journal of medicinal chemistry

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14

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Abstract

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In Vitro Study

Study Snapshot

Novel aromatic urea and amide analogues show antiproliferative activity against human tumor cell lines, with mechanisms unrelated to the acylation of glutamic acid at 198 on -tubulin.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, antiproliferative activity evaluation and structure-activity relationships of novel aromatic urea and amide analogues of N-phenyl-N'-(2-chloroethyl)ureas.

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