Synthesis and hypoglycemic activity of methyl-6-aryl(hetaryl)-5-(2-furanoyl)-3,6-dihydrotetrazolo[1,5-a]pyrimidine-4-carboxylates

doi:10.1134/S1070363216020134

Paper

Synthesis and hypoglycemic activity of methyl-6-aryl(hetaryl)-5-(2-furanoyl)-3,6-dihydrotetrazolo[1,5-a]pyrimidine-4-carboxylates

Published Mar 31, 2016 · V. L. Gein, T. M. Zamaraeva, V. V. Mishunin

Russian Journal of General Chemistry

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Abstract

Three-component reaction of methyl 2-furanoylpyruvate with an aromatic aldehyde and 5-aminotetrazole monohydrate has afforded methyl 6-aryl(hetaryl)-5-(2-furanoyl)-3,6-dihydrotetrazolo[1,5-a]-pyrimidine-4-carboxylates. Hypoglycemic activity of the prepared compounds has been studied.

Study Snapshot

Methyl-6-aryl(hetaryl)-5-(2-furanoyl)-3,6-dihydrotetrazolo[1,5-a]-pyrimidine-4-carboxylates show promising hypoglycemic activity when combined with a thia

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and hypoglycemic activity of methyl-6-aryl(hetaryl)-5-(2-furanoyl)-3,6-dihydrotetrazolo[1,5-a]pyrimidine-4-carboxylates

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References

Synthesis and antifungal activity of 9-aryl-8-(2-thienyl)-4,9-dihydrotetrazolo-[1′,5′-1,2]pyrimido[4,5-d]pyridazin-5(6 h)-ones

The synthesized 9-aryl-8-(2-thienyl)-4,9-dihydrotetrazolo[1′,5′-1,2]pyrimido[4,5-d]pyridazin-5(6H)-ones show promising antimicrobial activity.

Synthesis of methyl 7-aryl-6-(2-thenoyl)-4,7-dihydro-tetrazolo[1,5-a]pyrimidine-5-carboxylates and their reaction with hydrazine hydrate

This study demonstrates a facile, solvent-free method for synthesizing 9-aryl-8-(2-thienyl)-4,9-dihydrotetrazolo[1′,5′: 1,2]pyrimido[4,5-d]pyridazin-5(6

Synthesis and antimicrobial activity of methyl-7-aryl(heteryl)-6-(2-thienoyl)-4,7- dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylates

Methyl-7-aryl(heteryl)-6-(2-thienoyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylates show promising antimicrobial activity against various bacteria and fungi.

Citations

Synthesis of (E)-5-Arylvinyl-7-methyltetrazolo[1,5-a]pyrimidines

This study demonstrates the facile synthesis of (E)-5-arylvinyl-7-methyltetrazolo[1,5-a]pyrimidines using a three-component reaction of 5-aminotetrazole, aromatic aldehydes, and acetylacetone under solvent-

Synthesis of (7-Aryl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidin-6-yl)(phenyl)methanones

This study demonstrates the facile synthesis of (7-Aryl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidin-6-yl)(phenyl)methanones using three-component condensation under solvent-free conditions.

Ethyl 5-methyl-7-(4-morpholinophenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate

The synthesized compound exhibits a unique molecular structure and potential as a novel drug target.

5-Aminotetrazole as a building block for multicomponent reactions (review)

5-Aminotetrazole is a useful building block in organic synthesis, playing a role as a 1,3-binucleophilic reagent in various multicomponent reactions.

Developments in Tetrazole Chemistry (2009–16)

Tetrazole chemistry has advanced in recent years, with new synthetic conditions and promising new directions in research emerging.