Synthesis and antiarrhythmic activity of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols.

doi:10.1021/JM00105A002

Paper

Synthesis and antiarrhythmic activity of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols.

Published 1991 · M. Hoefle, L. T. Blouin, Robert W. Fleming

Journal of medicinal chemistry

Q1 SJR score

5

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

A series of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols was evaluated for antiarrhythmic activity in the coronary artery ligated dog model. Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group afforded the best antiarrhythmic agents in this series and was essential for long duration of action. This investigation indicated that quaternary ammonium salts were not essential for a long duration of action. It was also shown that the antiarrhythmic activity could be separated from the tachycardia frequently caused by this type of agent.

Non-RCT

Animal Study

Study Snapshot

Alpha-[(diarylmethoxy)methyl]-1-piperidineethanols show promising antiarrhythmic activity, with 2,6-dimethylpiperidine being essential for long-lasting action and quaternary ammonium salts not being essential for long-term action.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis and antiarrhythmic activity of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols.

Sign up to use Study Snapshot

References

Citations

FeBr3-catalyzed regioselective hydroxysulfenylation of N-allylsulfonamides with sulfonyl hydrazides

FeBr3-catalyzed regioselective hydroxysulfenylation of unactivated C C double bonds produces various -hydroxysulfides in moderate to good isolated yields.

Design, Multicomponent Synthesis and Characterization of Diversely Substituted Pyrazolo[1,5‐a] Pyrimidine Derivatives

Acetoactanilide, aldehyde, and 5-amino-N-cyclohexyl-3-(methylthio)-1H-pyrazole-4-carboxamide can effectively synthesize novel pyrazolopyrimidine derivatives in isopropyl alcohol.

Thymidylate synthase inhibition: A structure‐based rationale for drug design

Non-analog antifolate inhibitors show potential for future drug discovery studies by targeting thymidylate synthase, a key enzyme in antiproliferative diseases and cancer therapy.