Synthesis and antibacterial activity of some imidazo[1,2-a]pyrimidine derivatives.

doi:10.1248/CPB.40.1170

Paper

Synthesis and antibacterial activity of some imidazo[1,2-a]pyrimidine derivatives.

Published May 25, 1992 · Y. Rival, G. Grassy, G. Michel

Chemical & pharmaceutical bulletin

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257

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Abstract

A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The "in vitro" antibacterial activity of these compounds and their corresponding alpha-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.

In Vitro Study

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Study Snapshot

Imidazo[1,2-a]pyrimidine derivatives show potent antibacterial activity against various bacteria and Mycobacterium species, warranting further investigation for potential pharmaceutical applications.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and antibacterial activity of some imidazo[1,2-a]pyrimidine derivatives.

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References

Citations

Sustainable Synthesis of Polyfluoro-Pyrimido [1,2-a] Benzimidazole Derivatives Using a Tandem Strategy─Ultrasound and an Integrated Continuous Flow System.

This study developed a novel ultrasound technique for synthesis of polyfluoro-pyrimidine derivatives using easily accessible starting materials in an eco-friendly, efficient, and scalable manner.

Synthesis, Characterization, and antiviral evaluation of New Chalcone-Based Imidazo[1,2-a]pyridine Derivatives: Insights from in vitro and in silico Anti-HIV studies.

New Chalcone-based imidazo[1,2-a]pyridine derivatives show promising antiviral properties against HIV-1 and HIV-2, with potential for further structural optimization to enhance bioavailability and therapeutic potential.

Discovery of Imidazo[1,2‐a]pyrimidine–Schiff Base Derivatives as Potent Antifungal Agents Against Fusarium oxysporum f. sp. albedinis: Synthesis, Crystal Structure, Biological Evaluation, Homology Modeling, and Docking Analysis

Imidazo[1,2a]pyrimidine-Schiff base derivatives show potent antifungal activity against Fusarium oxysporum f. sp. albedinis, a major threat to date palm cultivation in North Africa and the Middle East.

Synthesis, crystal structure, and antiviral evaluation of new imidazopyridine-schiff base derivatives: in vitro and in silico anti-HIV studies

New imidazopyridine-schiff base derivatives show promising antiviral activity against HIV-1 and HIV-2, but require further structural modifications for enhanced bioavailability and therapeutic potential.

One Pot Synthesis of C3-Sulfurized Imidazolo [1,2-a] Pyridines.

A facile and efficient strategy using a-bromoketones, aminopyridines, and benzazol effectively synthesized imidazole [1,2-a]pyridine sulfides in moderate to good yields.

FeBr3-catalysed synthesis of 3-aroylimidazo[1,2-a]pyridine and 3,3′-(arylmethylene)bis(2-phenylimidazo[1,2-a]pyridines) derivatives from 2-arylimidazo[1,2-a]pyridines and aromatic aldehydes: an investigation about mechanistic insights

FeBr3-catalyzed synthesis of 3-aroylimidazo[1,2-a]pyridine derivatives in high yields, using oxygen as the principal oxidant, is also effective under an argon atmosphere.

The synthesis of Fe3O4@SiO2-NNO-CuII nanocatalyst and investigation of its application in the synthesis of imidazo[1,2-a]pyridines

The Fe3O4@SiO2-NNO-CuII nanocatalyst efficiently recycles copper ions for the synthesis of imidazo[1,2-a]pyridines in high yields and short reaction times.