A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The "in vitro" antibacterial activity of these compounds and their corresponding alpha-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.

Imidazo[1,2-a]pyrimidine derivatives show potent antibacterial activity against various bacteria and Mycobacterium species, warranting further investigation for potential pharmaceutical applications.

Paper

Synthesis and antibacterial activity of some imidazo[1,2-a]pyrimidine derivatives.

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