Synthesis and antimicrobial activity of certain imidazo[1,2-a]pyrimidines.

doi:10.1021/JM00246A018

Paper

Synthesis and antimicrobial activity of certain imidazo[1,2-a]pyrimidines.

Published Dec 1, 1975 · Revanker Gr, Matthews Tr, Robins Rk

Journal of Medicinal Chemistry

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46

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0

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Abstract

: A series of 5-substituted and 5,7-disubstituted imidazo[1,2-a]pyrimidines has been prepared. The in vitro antimicrobial activity of these compounds against a variety of microorganisms is reported. 5-n-Octylaminoimidazo[1,2-a]pyrimidine exhibited significant activity against all the microorganisms studied.

In Vitro Study

Study Snapshot

5-n-Octylaminoimidazo[1,2-a]pyrimidine shows significant antimicrobial activity against various microorganisms, making it a promising candidate for antimicrobial drug discovery.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and antimicrobial activity of certain imidazo[1,2-a]pyrimidines.

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References

Citations

Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy.

The optimized triazolopyrimidine derivative 26a shows potent P2X3 receptor antagonistic activity and high selectivity versus other P2XR subtypes, offering potential for neurological inflammatory diseases like neuropathic pain and chronic cough.

Binuclear Ag(I) and Cu(I)- complexes supported by imidazo[1,2-α]pyrimidine; synthesis, structure and DFT studies

Imidazo[1,2-]pyrimidine supports luminescent dinuclear Ag(I) and Cu(I) complexes, with each Ag(I) coordinating by three N pym from each ligand.

Synthesis of imidazole-fused nitrogen-bridgehead heterocycles catalysed by lipase and their antifungal and antimicrobial bioactivity

Selective synthesis of imidazo[1,2-a]pyridine-based heterocycles using porcine pancreatic lipase yields antimicrobial and antifungal derivatives with good-to-excellent yields.

Iodine and DMSO as Surrogate of Hazardous Metal and Non‐Metal Reagents in Organic Synthesis

Iodine and DMSO can be used as environmentally friendly alternatives to expensive metal and non-metal reagents in organic synthesis, offering a more sustainable solution for valuable chemical scaffolds.

HFIP promoted thio(hetero)arylation of imidazoheterocycles under metal- and base-free conditions.

This study developed a new method for HFIP-promoted thio(hetero)arylation of imidazoheterocycles under metal- and base-free conditions, leading to the synthesis of compounds with significant biological properties.

Sequential Regioselective Di-organochalcogenations of Imidazo[1,2-a]pyrimidines using I2/H3PO4 in DMSO.

This study presents a novel sequential dichalcogenation strategy for functionalizing imidazo[1,2-a]pyrimidine cores on the C6-position, achieving excellent regioselectivity and yields.